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Optimizing Caffeine Use and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review, Meta-analysis, and Application of Grading of Recommendations Assessment, Development, and Evaluation Methodology

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Optimizing Caffeine Use and Risk of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review, Meta-analysis, and Application of Grading of Recommendations Assessment, Development, and Evaluation Methodology

ABSTRACT

DOI: 10.1016/j.clp.2018.01.012
KEY POINTS  
Earlier initiation of caffeine, compared to later initiation, is associated with a decreased risk of bronchopulmonary dysplasia.  High-dose caffeine, compared to standard-dose caffeine, may reduce the risk of bronchopulmonary dysplasia.  The overall quality of evidence of studies on the dose and timing of caffeine and risk of bronchopulmonary dysplasia is low.  Higher-quality evidence is needed to understand the risks and benefits of early initiation and high-dose caffeine to decrease the risk of bronchopulmonary dysplasia.

 

ABSTRACT

DOI: 10.1016/j.clp.2018.01.012
KEY POINTS  
Earlier initiation of caffeine, compared to later initiation, is associated with a decreased risk of bronchopulmonary dysplasia.  High-dose caffeine, compared to standard-dose caffeine, may reduce the risk of bronchopulmonary dysplasia.  The overall quality of evidence of studies on the dose and timing of caffeine and risk of bronchopulmonary dysplasia is low.  Higher-quality evidence is needed to understand the risks and benefits of early initiation and high-dose caffeine to decrease the risk of bronchopulmonary dysplasia.

 

Pubblicato su NOW: 08-11-2018
Pubblicato sulla rivista: 01-06-2018